Crospovidone

Unlike povidone, crospovidone is completely insoluble in solvents and the corresponding products cannot be named according to a K-value or a molecular weight. The product differentiation is conducted mainly by the particle-size distribution.

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PRODUCTS DETAILS

product detail

Pharmaceutical Excipient Crospovidone is a crosslinked PVP,insoluble PVP,it is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.Its; classified as Crospovidone Type A and Type B according to the different particle size.

Key Technical Parameters:

Product Crospovidone Type A Crospovidone Type B
Appearance White or yellowish-white powder or flakes
Identifications A.Infrared Absorption
B.No blue color develops.
C.A Suspension is formed and no clear solution is obtained within 15 min.
D.Majority of particles are in the range 50 ~300 μm is type A,majority of particles are in the range 5~50 μm
Solubility Practically insoluble in water,in alcohol and in methylene chloride
Water- soluble substances 1.0% max 1.0% max
pH((1% in water)   5.0 –8.0 5.0 –8.0
Loss on Drying 5.0% max. 5.0% max.
Sulphated Ash 0.1% max. 0.1% max.
Nitrogen content                      11.0 -12.8 % 11.0 -12.8 %
Impurity A 10 ppm max. 10 ppm max.
Peroxide(As H2O2) 400 ppm max. 1000 ppm max.
Heavy Metals 10 ppm max. 10 ppm max.

Applications:

Crospovidone are widely used as 1)Disintergrating agent,2)Stabilizer for suspension,3)Moisture Absorbent, 4)Complextant of Polyphenols and Tannin for the extract formulations.

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Food Grade PVPP is a crosslinked PVP,insoluble,it is hygroscopic,insoluble in water and all other common solvents,but it swells rapidly in aqueous solutbition without any gel froms.

Key Technical Parameters:

Product PVPP (One Way) PVPP(Regenerate)
Appearance White to off-white,hygroscopic,free-flowing powder
Solubility Insoluble in water and other common solvents.
Odour of the suspension Faint,Typical
Nitrogen 11.0-12.8% 11.0-12.8%
Heavy metals(As Pb) 10ppm max. 10ppm max.
Lead 2 ppm max. 2 ppm max.
Arsenic 2 ppm max. 2 ppm max.
pH(1% in Water Suspension) 5.0-8.0 5.0-8.0
Sulphated Ash 0.4% max. 0.4% max.
Water soluble substances 0.5% max. 0.5% max.
Solubility in Acetic Acid/Ethnol 1.0% max. 1.0% max.
Peroxides 400 ppm max. 400 ppm max.
N,N-Divinylimidazolidione 2ppm max. 2ppm max.
N-Vinylpyrrolidone 10 ppm max. 10 ppm max.
Water 5.0% max. 5.0% max.
Paticle Size / /

Applications:

Thanks to it’s insoluble properties in water and other common solvents,PVPP is widely acted as stabilizers & clarifier for Beer/Wine and other beverages products,it can romove polyphenols and tannins substances during the Beer/Wine/Beverage processing.



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